Gene discovery through expressed sequence Tag sequencing in Trypanosoma cruzi.

  title={Gene discovery through expressed sequence Tag sequencing in Trypanosoma cruzi.},
  author={R E Verd{\'u}n and Nicola Di Paolo and Tur{\'a}n P{\'e}ter Urm{\'e}nyi and Edson Rondinelli and Alberto Carlos C Frasch and Daniel S{\'a}nchez},
  journal={Infection and immunity},
  volume={66 11},
Analysis of expressed sequence tags (ESTs) constitutes a useful approach for gene identification that, in the case of human pathogens, might result in the identification of new targets for chemotherapy and vaccine development. As part of the Trypanosoma cruzi genome project, we have partially sequenced the 5' ends of 1, 949 clones to generate ESTs. The clones were randomly selected from a normalized CL Brener epimastigote cDNA library. A total of 14.6% of the clones were homologous to… CONTINUE READING


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Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily

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