[Gene diagnosis of hemophilia B by multiple STR analysis].


OBJECTIVE To establish a simple, rapid genetic diagnostic system for haemophilia B. METHODS The polymorphisms of eight STR loci in 87 normal persons and 8 haemophilia B families were assayed by PCR and genescan, and the linkage relations were analysed. RESULTS Six of the eight STR loci can provide genetic information for haemophilia B, and the heterozygosity is 0.50 approximately 0.83, PIC 0.39 approximately 0.80, and DP 0.66 approximately 0.94. CONCLUSION Combination of multiple STR loci analysis could be effective method for genetic diagnosis of haemophilia B.

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@article{Liu2002GeneDO, title={[Gene diagnosis of hemophilia B by multiple STR analysis].}, author={Xiangfan Liu and Xuefeng Wang and Qishi Fan and Haiyan Chu and Yi Fang and Hongli Wang}, journal={Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi}, year={2002}, volume={23 3}, pages={147-50} }