Gene delivery to cartilage defects using coagulated bone marrow aspirate

  title={Gene delivery to cartilage defects using coagulated bone marrow aspirate},
  author={Arnulf Pascher and G Palmer and Andr{\'e} Steinert and T J Oligino and Elvire Gouze and J N Gouze and Oliver Betz and Myron Spector and P E - Pathcentre Robbins and C H Evans and S C. Ghivizzani},
  journal={Gene Therapy},
The long-term goal of the present study is to develop a clinically applicable approach to enhance natural repair mechanisms within cartilage lesions by targeting bone marrow-derived cells for genetic modification. To determine if bone marrow-derived cells infiltrating osteochondral defects could be transduced in situ, we implanted collagen–glycosaminoglycan (CG) matrices preloaded with adenoviral vectors containing various marker genes into lesions surgically generated in rabbit femoral… CONTINUE READING
37 Citations
37 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees

  • Z Mi
  • Arthritis Res
  • 2003

Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction

  • C Kaps
  • Arthritis Rheum
  • 2002

Similar Papers

Loading similar papers…