Gene delivery to cartilage defects using coagulated bone marrow aspirate

@article{Pascher2004GeneDT,
  title={Gene delivery to cartilage defects using coagulated bone marrow aspirate},
  author={Arnulf Pascher and G Palmer and Andr{\'e} Steinert and T J Oligino and Elvire Gouze and J N Gouze and Oliver Betz and Myron Spector and P E - Pathcentre Robbins and C H Evans and S C. Ghivizzani},
  journal={Gene Therapy},
  year={2004},
  volume={11},
  pages={133-141}
}
The long-term goal of the present study is to develop a clinically applicable approach to enhance natural repair mechanisms within cartilage lesions by targeting bone marrow-derived cells for genetic modification. To determine if bone marrow-derived cells infiltrating osteochondral defects could be transduced in situ, we implanted collagen–glycosaminoglycan (CG) matrices preloaded with adenoviral vectors containing various marker genes into lesions surgically generated in rabbit femoral… CONTINUE READING
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