Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.

@article{Ren2016GeneDA,
  title={Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.},
  author={Qian Ren and Min Jian Ma and Tamaki Ishima and Christophe H P Morisseau and Jun Yang and Karen M. Wagner and Ji-chun Zhang and Chun Yang and Wei Yao and Chao Dong and Mei Han and Bruce D Hammock and Kenji Hashimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 13},
  pages={E1944-52}
}
Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the inflammation that is involved in depression. Thus, we examined here the role of sEH in depression. In both inflammation and social defeat stress models of depression, a potent sEH inhibitor, TPPU, displayed rapid… CONTINUE READING
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