Gene defect behind APECED: a new clue to autoimmunity.

  title={Gene defect behind APECED: a new clue to autoimmunity.},
  author={Petra Bj{\"o}rses and Johanna M Aaltonen and Nina Horelli-Kuitunen and M L Yaspo and L. Peltonen},
  journal={Human molecular genetics},
  volume={7 10},
The molecular background of human autoimmunity is poorly understood. Although many autoimmune diseases have a genetic basis, the actual disease appearance results from a complex interplay between genes and environment and thus these diseases represent typical multifactorial diseases. Even with molecular tools provided by the Human Genome Project, it still remains a challenge to identify the predisposing DNA variants behind such multifactorial traits. Two strategies have been suggested to… CONTINUE READING


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