Gene-culture coevolution between cattle milk protein genes and human lactase genes

@article{BejaPereira2003GenecultureCB,
  title={Gene-culture coevolution between cattle milk protein genes and human lactase genes},
  author={A. Beja-Pereira and G. Luikart and P. England and D. Bradley and O. Jann and G. Bertorelle and A. Chamberlain and T. P. Nunes and S. Metodiev and N. Ferrand and G. Erhardt},
  journal={Nature Genetics},
  year={2003},
  volume={35},
  pages={311-313}
}
Milk from domestic cows has been a valuable food source for over 8,000 years, especially in lactose-tolerant human societies that exploit dairy breeds. We studied geographic patterns of variation in genes encoding the six most important milk proteins in 70 native European cattle breeds. We found substantial geographic coincidence between high diversity in cattle milk genes, locations of the European Neolithic cattle farming sites (>5,000 years ago) and present-day lactose tolerance in Europeans… Expand

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References

SHOWING 1-10 OF 12 REFERENCES
Marker-derived phylogeny of European cattle supports demic expansion of agriculture.
TLDR
Positive partial correlations between genetic distance and time elapsed since introduction of farming while keeping geographical distances constant, and regular patterns over thousands of kilometers indicate that large-scale cattle population movements together with human migration from the Near East into Europe across the Balkans are the most likely explanation for the genetic distances observed in data. Expand
Nucleotide sequence evolution at the kappa-casein locus: evidence for positive selection within the family Bovidae.
TLDR
The pattern of nucleotide substitution in kappa-casein sequences for distantly related bovid taxa demonstrates that positive selection has accelerated their divergence at the amino acid sequence level. Expand
Haplotype diversity of the myostatin gene among beef cattle breeds
TLDR
Muscular hypertrophy (namely nt821(del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations arose in a single breed, were highly selected and have since scarcely evolved to other populations. Expand
Genetic evidence for Near-Eastern origins of European cattle
The limited ranges of the wild progenitors of many of the primary European domestic species point to their origins further east in Anatolia or the fertile crescent. The wild ox (Bos primigenius),Expand
Early Weaning of Neolithic Domestic Cattle (Bercy, France) Revealed by Intra-tooth Variation in Nitrogen Isotope Ratios
TLDR
Results suggest that the Neolithic calves were weaned early, which could reflect either a shorter lactation for Neolithic cows, or early weaning imposed by the herder in order to reserve a bigger proportion of milk production for human consumption. Expand
A microsatellite survey of cattle from a centre of origin: the Near East
TLDR
It was possible to demonstrate that Near Eastern cattle exhibited significantly higher levels of allelic diversity than breeds from other regions, which is consistent with the view that this region represents a primary domestication centre for Bos taurus cattle. Expand
Genetic structure of seven European cattle breeds assessed using 20 microsatellite markers.
TLDR
It is demonstrated that a simple allele-sharing genetic distance parameter can be used to construct a dendrogram of relationships among animals and reflects an extensive underlying kinship structure, particularly for the Swiss Simmental breed and four breeds originating from the British Isles. Expand
Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance
TLDR
The hypothesis that malaria has had a major impact on humans only since the introduction of agriculture within the past 10,000 years is supported and the locus of “A−” and ”Med” mutations provides a striking example of the signature of selection on the human genome. Expand
Genetic analysis of host-parasite coevolution in human malaria.
TLDR
Combined genetic, immunological and mathematical analysis of host and parasite variants in natural populations can identify some mechanisms driving host-parasite coevolution. Expand
Direct demonstration of milk as an element of archaeological economies
The stable carbon isotope (delta13C) compositions of individual fatty acid components of remnant fats preserved in archaeological pottery vessels show that dairying was a component of archaeologicalExpand
...
1
2
...