Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.

@article{Moroni2005GeneCN,
  title={Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study.},
  author={Mauro Moroni and Silvio Marco Veronese and Silvia Benvenuti and Giovanna Marrapese and Andrea Sartore-Bianchi and Federica Di Nicolantonio and Marcello Gambacorta and Salvatore Siena and Alberto Bardelli},
  journal={The Lancet. Oncology},
  year={2005},
  volume={6 5},
  pages={279-86}
}
BACKGROUND The antiepidermal growth factor receptor (antiEGFR) monoclonal antibodies cetuximab and panitumumab have good clinical activity in about 10% of patients with metastatic colorectal cancer that is resistant to chemotherapy. The molecular mechanisms underlying clinical response or resistance to these agents are unknown. METHODS Tumours from 31… CONTINUE READING