Gene conversion confined to a direct repeat of the acceptor splice site generates allelic diversity at human glycophorin (GYP) locus.

@article{Huang1992GeneCC,
  title={Gene conversion confined to a direct repeat of the acceptor splice site generates allelic diversity at human glycophorin (GYP) locus.},
  author={Chenghan Huang and Masaki Kikuchi and JAMIE McCREARY and Olga O. Blumenfeld},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 5},
  pages={3336-42}
}
The glycophorin locus (GYP) on the long arm of chromosome 4 encodes antigens of the MNSs blood group system and displays considerable allelic variation among human populations. The genomic structure and organization of a variant glycophorin allele specifying a novel Miltenberger (Mi)-related phenotype, MiX, were examined. This variant probably arose from a gene conversion event involving a direct repeat of the acceptor splice site. Southern blot analysis indicated that MiX gene derived its 5… CONTINUE READING

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