• DOI:10.1038/nrg2193
Corpus ID: 205484180

Gene conversion: mechanisms, evolution and human disease

@article{Chen2007GeneCM,
  title={Gene conversion: mechanisms, evolution and human disease},
  author={J. Chen and D. Cooper and N. Chuzhanova and C. F{\'e}rec and G. Patrinos},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={762-775}
}

• J. Chen, D. Cooper, +2 authors G. Patrinos
• Published 2007
• Biology, Medicine
• Nature Reviews Genetics

Gene conversion, one of the two mechanisms of homologous recombination, involves the unidirectional transfer of genetic material from a 'donor' sequence to a highly homologous 'acceptor'. Considerable progress has been made in understanding the molecular mechanisms that underlie gene conversion, its formative role in human genome evolution and its implications for human inherited disease. Here we assess current thinking about how gene conversion occurs, explore the key part it has played in… Expand

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