• Corpus ID: 40978807

Gene conversion: a hitherto overlooked parameter in population genetics.

@article{Gutz1976GeneCA,
  title={Gene conversion: a hitherto overlooked parameter in population genetics.},
  author={Herbert Gutz and John F. Leslie},
  journal={Genetics},
  year={1976},
  volume={83 4},
  pages={
          861-6
        }
}
Gene conversion causes deviations from the 2:2 segregation of allele pairs in meiosis. Thus, gene conversion is a potential cause for changes of allele frequencies in populations. Equations are derived for the effects of conversion in a large random-mating population. The influence of gene conversion on allele frequencies is compared with that of spontaneous mutation and meiotic drive. 
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The proportion of GC→AT versus AT→GC polymorphic mutations in a locus is correlated with its GC content, which implies the action of forces that favour GC over AT base pairs, which are apparently strongest in GC-rich sequences.
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It is shown that gBGC might have little impact on the total amount of heterosis but could greatly affect its genetic basis, through an analysis of the interaction between gB GC and selection in subdivided populations.
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