• Corpus ID: 40978807

Gene conversion: a hitherto overlooked parameter in population genetics.

  title={Gene conversion: a hitherto overlooked parameter in population genetics.},
  author={Herbert Gutz and John F. Leslie},
  volume={83 4},
Gene conversion causes deviations from the 2:2 segregation of allele pairs in meiosis. Thus, gene conversion is a potential cause for changes of allele frequencies in populations. Equations are derived for the effects of conversion in a large random-mating population. The influence of gene conversion on allele frequencies is compared with that of spontaneous mutation and meiotic drive. 
The relative importance of meiotic gene conversion, selection and mutation pressure, in population genetics and evolution
Using observed conversion parameters from various fungi, it is shown that conversion is generally much more important than mutation pressure and may be of greater or lesser importance than selection, depending on dominance and the strength of selection and conversion forces for the alleles involved.
The effect of intragenic recombination on the number of alleles in a finite population.
The results of theory and Monte Carlo simulation of the two-site model demonstrate that intragenic recombination significantly increases the mean and variance of the number of alleles when the rates of mutation and recombination are as large as the reciprocal of the population size.
High-frequency germ line gene conversion in transgenic mice
It is demonstrated that gene conversion in mice is an active recombinational process leading to nonparental gametic haplotypes, and a process may exist to uncouple gene pairs from frequent conversion-mediated homogenization.
A selfish origin for recombination.
Molecular population genomics: a short history.
The results of surveys of levels of genome-wide variability using DNA resequencing studies are discussed and the effects of deleterious mutations on population fitness and the possible role of Hill-Robertson interference in shaping patterns of sequence variability are discussed.
Surprising Fitness Consequences of GC-Biased Gene Conversion: I. Mutation Load and Inbreeding Depression
A population genetics model is developed to predict the consequences of gBGC on the mutation load and inbreeding depression and suggests that gB GC may have nonnegligible fitness consequences and could play a significant role in the evolution of genetic systems.
The properties of meiotic gene conversion important in its effects on evolution
The high proportion of non-zero y values in all fungi, with large departures from zero being most extreme in Ascobolus and Sordaria brevicollis, shows that gene conversion could often be an important force in changing allele frequencies in favour of mutant or wild-type in these organisms.
Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila
The proportion of GC→AT versus AT→GC polymorphic mutations in a locus is correlated with its GC content, which implies the action of forces that favour GC over AT base pairs, which are apparently strongest in GC-rich sequences.
Surprising Fitness Consequences of GC-Biased Gene Conversion. II. Heterosis
It is shown that gBGC might have little impact on the total amount of heterosis but could greatly affect its genetic basis, through an analysis of the interaction between gB GC and selection in subdivided populations.