Gene coexpression analysis in single cells indicates lymphomyeloid copriming in short-term hematopoietic stem cells and multipotent progenitors.

@article{Gautreau2010GeneCA,
  title={Gene coexpression analysis in single cells indicates lymphomyeloid copriming in short-term hematopoietic stem cells and multipotent progenitors.},
  author={Laetitia Gautreau and Amine Boudil and Val{\'e}rie Pasqualetto and Lamia Skhiri and Laure Grandin and M do C Monteiro and Jean-Philippe Jais and Sophie Ezine},
  journal={Journal of immunology},
  year={2010},
  volume={184 9},
  pages={
          4907-17
        }
}
Progressive restriction to a differentiation pathway results from both activation and silencing of particular gene expression programs. To identify the coexpression and the expression levels of regulatory genes during hematopoietic stem cell (HSC) differentiation toward the T cell branch, we applied a new single-cell RT-PCR technique to analyze the simultaneous expression of 13 genes in 9 functionally purified populations from the bone marrow and the thymus. We report in this paper that Lin… CONTINUE READING