Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas

@inproceedings{Eising2016GeneCA,
  title={Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas},
  author={Else Eising and Sjoerd M. H. Huisman and Ahmed Y. Mahfouz and Lisanne S. Vijfhuizen and Verneri Anttila and Bendik S Winsvold and Tobias Kurth and M. Arfan Ikram and Tobias M. Freilinger and Jaakko Kaprio and Dorret I. Boomsma and Cornelia M van Duijn and M R J{\"a}rvelin and John Anker H Zwart and L. A. N. Quaye and David P. Strachan and Christian Kubisch and Martin Dichgans and George Davey Smith and K{\'a}ri Stef{\'a}nsson and Aarno V Palotie and Daniel Chasman and Michel D. Ferrari and Gisela M. Terwindt and Boukje de Vries and Dale R. Nyholt and Boudewijn P. F. Lelieveldt and Arn M J M van den Maagdenberg and Marcel J. T. Reinders},
  booktitle={Human Genetics},
  year={2016}
}
Migraine is a common disabling neurovascular brain disorder typically characterised by attacks of severe headache and associated with autonomic and neurological symptoms. Migraine is caused by an interplay of genetic and environmental factors. Genome-wide association studies (GWAS) have identified over a dozen genetic loci associated with migraine. Here, we integrated migraine GWAS data with high-resolution spatial gene expression data of normal adult brains from the Allen Human Brain Atlas to… CONTINUE READING