Gene cloning and overproduction of low-specificity d-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug

@article{Liu2000GeneCA,
  title={Gene cloning and overproduction of low-specificity d-threonine aldolase from Alcaligenes xylosoxidans and its application for production of a key intermediate for parkinsonism drug},
  author={June Qingxia Liu and Masayasu Odani and Tadashi Yasuoka and Tohru Dairi and Nobuya Itoh and Michihiko Kataoka and S. Ohshima A. Shimizu and Hideaki Yamada},
  journal={Applied Microbiology and Biotechnology},
  year={2000},
  volume={54},
  pages={44-51}
}
The dtaAX gene encoding a pyridoxal 5′-phosphate (pyridoxal-P)-dependent low-specificity d-threonine aldolase was cloned from the chromosomal DNA of Alcaligenes xylosoxidans IFO 12669. It contains an open reading frame consisting of 1,134 nucleotides corresponding to 377 amino acid residues. The predicted amino acid sequence displayed 54% identity with that of d-threonine aldolase from gram-positive bacteria Arthrobacter sp. DK-38, but showed no significant similarity with those of other known… CONTINUE READING

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