Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

@inproceedings{Zhao2011GeneBA,
  title={Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation},
  author={Rui Zhao and Tetsuya Nakamura and Yu Fu and Zsolt I. L{\'a}z{\'a}r and David L. Spector},
  booktitle={Nature Cell Biology},
  year={2011}
}
Although transmission of the gene expression program from mother to daughter cells has been suggested to be mediated by gene bookmarking, the precise mechanism by which bookmarking mediates post-mitotic transcriptional re-activation has been unclear. Here, we used a real-time gene expression system to quantitatively demonstrate that transcriptional activation of the same genetic locus occurs with a significantly more rapid kinetics in post-mitotic cells versus interphase cells. RNA polymerase… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Selective inhibition of BET bromodomains

  • P Filippakopoulos
  • Nature
  • 2010

Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain

  • T Umehara
  • J Biol Chem
  • 2010

Similar Papers

Loading similar papers…