Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling.

@article{Ferreira2017GenebasedAO,
  title={Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling.},
  author={Manuel A. R. Ferreira and Rick Jansen and Gonneke A H M Willemsen and Brenda W J H Penninx and Lisa M Bain and Cristina T Vicente and J A Revez and Melanie C Matheson and Jennie Hui and Joyce Y. Tung and Svetlana Baltic and Peter Niels le Sou{\"e}f and Grant W. Montgomery and Nicholas G. Martin and Colin Francis Robertson and Alan L. James and Phillip J. Thompson and Dorret I. Boomsma and John L. Hopper and David A. Hinds and Rhiannon B Werder and Simon Phipps},
  journal={The Journal of allergy and clinical immunology},
  year={2017},
  volume={139 4},
  pages={1148-1157}
}
BACKGROUND Hundreds of genetic variants are thought to contribute to variation in asthma risk by modulating gene expression. Methods that increase the power of genome-wide association studies (GWASs) to identify risk-associated variants are needed. OBJECTIVE We sought to develop a method that aggregates the evidence for association with disease risk across expression quantitative trait loci (eQTLs) of a gene and use this approach to identify asthma risk genes. METHODS We developed a gene… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS