Gene-asbestos interaction in malignant pleural mesothelioma susceptibility.

  title={Gene-asbestos interaction in malignant pleural mesothelioma susceptibility.},
  author={Sara Tunesi and Daniela Ferrante and Dario Mirabelli and Silvano Andorno and Marta Betti and Giovanni Fiorito and Simonetta Guarrera and Elisabetta Casalone and Monica Neri and Donatella Ugolini and Stefano Bonassi and Giuseppe Matullo and Irma Dianzani and Corrado Magnani},
  volume={36 10},
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, on average less than 10% of subjects highly exposed to asbestos develop MPM, suggesting the possible involvement of other risk factors. To identify the genetic factors that may modulate the risk of MPM, we conducted a gene-environment interaction analysis including asbestos exposure and 15 single nucleotide polymorphisms (SNPs) previously identified through a genome-wide… 

Tables from this paper

Matrix Metalloproteinases Polymorphisms as Baseline Risk Predictors in Malignant Pleural Mesothelioma

The MMP2 rs243865 polymorphism may have a protective role in malignant pleural mesothelioma development, even more evident in patients exposed to asbestos, implying a strong gene-environment interaction.

Pleural mesothelioma and lung cancer: the role of asbestos exposure and genetic variants in selected iron metabolism and inflammation genes

Investigating the association between Fe-metabolism and inflammasome gene variants and susceptibility to develop LC or MPM by comparing an asbestos-exposed population affected by LC with an “asbestos-resistant exposed population” found no association was found between NLRP1 and NLRP3 polymorphisms with susceptibility to developed MPM and LC.

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review

Several single nucleotide polymorphisms (SNPs) that may promote MM tumorigenesis as a result of an asbestos–gene interaction are identified, including SNPs in DNA repair, carcinogen detoxification and other genes previously associated with other malignancies.

Asbestos-Related Pleural Diseases: The Role of Gene-Environment Interactions

The results of the studies performed so far indicate that in addition to asbestos exposure, genetic factors as well as the interactions between genetic factors and asbestos exposure may have an important impact on the risk of asbestos-related pleural diseases, especially malignant mesothelioma.

Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes

Cumulative asbestos exposure in 14 patients with MPM and pathogenic germline variants in BAP1, CDKN2A, or DNA repair genes with that of 67 patients without germline variant in 94 cancer‐predisposing genes is compared.

The interaction of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs738409 increases the susceptibility to nonalcoholic steatohepatitis

Patients with NAFLD who have SAMM50-rs 738491 TT, PARVB-rs5764455 AA or PNPLA3-rs738409 GG genotypes are at higher risk of NASH, and these SNPs synergistically interact to increase the susceptibility to NASH.

Puzzling Results from BAP1 Germline Mutations Analysis in a Group of Asbestos-Exposed Patients in a High-risk Area of Northeast Italy.

The demonstration that BAP1 mutations are strongly associated with MM has provided a real breakthrough in the study of genetic predisposition in MM, that may explain why only a fraction of asbestos-exposed individuals go on to develop MM.

Genomics and Epigenetics of Malignant Mesothelioma

The discoveries made using high-throughput technologies, including novel insights obtained from the analysis of the non-coding transcriptome, and the clinical potential of these genetic and epigenetic findings in mesothelioma are reviewed.

SMO mutations confer poor prognosis in malignant pleural mesothelioma

SMO mutations were clearly associated with worse prognosis, and may be a therapeutic target but this needs to be confirmed in a prospective trial.



Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

The results showed that genetic risk factors may play an additional role in the development of MPM, and that these should be taken into account to better estimate individual MPM risk in individuals who have been exposed to asbestos.

Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases.

A genome-wide association study for malignant mesothelioma risk.

XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study.

Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia

An important, but not large, genetic component is suggested in mesothelioma in relatives, similar to many other cancers.

Mesothelioma in blood related subjects: report of 11 clusters among 1954 Italy cases and review of the literature.

BACKGROUND Malignant mesothelioma is a sporadic tumor related to asbestos. Its occurrence in blood relatives raises the question of potential contribution of predisposing factors. METHODS The study

Relation between exposure to asbestos and smoking jointly and the risk of lung cancer

  • P. Lee
  • Medicine
    Occupational and environmental medicine
  • 2001
Asbestos exposure multiplies risk of lung cancer by a similar factor in non-smokers and smokers, depending on the type of asbestos involved, and the nature, extent, and duration of exposure.