Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice.

@article{Cooper2003GeneAP,
  title={Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice.},
  author={Trevor Cooper and Andrea Wagenfeld and Gail A. Cornwall and Nelson Hsia and Sin Tak Chu and Marie-Claire Orgebin-Crist and Jo{\"e}l R. Drevet and Patrick Vernet and Cosmina Avram and Eberhard Nieschlag and C. -H. Yeung},
  journal={Biology of reproduction},
  year={2003},
  volume={69 5},
  pages={1750-62}
}
Transgenic male mice bearing inactive mutations of the receptor tyrosine kinase c-ros lack the initial segment of the epididymis and are infertile. Several techniques were applied to determine differences in gene expression in the epididymal caput of heterozygous fertile (HET) and infertile homozygous knockout (KO) males that may explain the infertility. Complementary DNA arrays, gene chips, Northern and Western blots, and immunohistochemistry indicated that some proteins were downregulated… CONTINUE READING

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