Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.

@article{Ooi2009GeneAO,
  title={Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.},
  author={Akishi Ooi and Shioto Suzuki and Kumiko Nakazawa and Jun Itakura and Issei Imoto and Hiroyuki Nakamura and Yoh Dobashi},
  journal={Anticancer research},
  year={2009},
  volume={29 1},
  pages={19-26}
}
BACKGROUND Among the combinations of coamplified genes, Myc and ERBB2 or EGFR have attracted much attention for their relevance to cytogenetics, carcinogenesis and cancer therapy. MATERIALS AND METHODS Gene amplification of Myc, ERBB2 and EGFR were examined on 97 formalin-fixed and paraffin-embedded gallbladder carcinomas, by fluorescence in situ hybridization (FISH). RESULTS FISH revealed three tumors had Myc amplification. By dual color FISH, one of these three tumors had two populations… CONTINUE READING
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