Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer.

@article{Apostolopoulou2007GeneAI,
  title={Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer.},
  author={Kalliopi Apostolopoulou and Ioannis S. Pateras and Konstantinos Evangelou and Petros K Tsantoulis and Michalis Liontos and Christos N. Kittas and Dina G. Tiniakos and Athanassios Kotsinas and Carlos Cordon-Cardo and Vassilis G Gorgoulis},
  journal={The Journal of pathology},
  year={2007},
  volume={213 3},
  pages={294-302}
}
ZBTB7A (Pokemon) is a member of the POK family of transcriptional repressors. Its main function is the suppression of the p14ARF tumour suppressor gene. Although ZBTB7A expression has been found to be increased in various types of lymphoma, there are no reports dealing with its expression in solid tumours. Given that p14(ARF) inhibits MDM2, the main negative regulator of p53, we hypothesized that overexpression of ZBTB7A could lead indirectly to p53 inactivation. To this end, we examined the… CONTINUE READING

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