Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

@article{Hafsi2012GeneAI,
  title={Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).},
  author={Sameh Hafsi and Franca Maria Pezzino and Saverio Candido and Giovanni Ligresti and Demetrios A. Spandidos and Zohra Soua and James Andrew McCubrey and Salvatore Travali and Massimo Libra},
  journal={International journal of oncology},
  year={2012},
  volume={40 3},
  pages={639-44}
}
The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signaling pathway involved in the regulation of cell growth. Dysregulated signaling of this pathway may be associated with activating mutations of PI3K-related… CONTINUE READING

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