Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.

Abstract

Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome… (More)
DOI: 10.1016/j.ajhg.2014.05.010

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@article{Simino2014GeneageII, title={Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.}, author={Jeannette Simino and Gang Shi and Joshua C Bis and Daniel Chasman and Georg B. Ehret and Xiangjun Gu and Xiuqing Guo and Shih-Jen Hwang and Eric J. G. Sijbrands and Albert V. Smith and Germaine C. Verwoert and Jennifer Lynn Bragg-Gresham and Gemma Cadby and Peng Chen and Ching-Yu Cheng and T. Corre and Rudolf A de Boer and Anuj Goel and Toby Johnson and Chiea Chuen Khor and Carla Llu{\'i}s-Ganella and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Ilja M. Nolte and Xueling Sim and Siim S{\~o}ber and Peter J van der Most and Niek Verweij and Jing Hua Zhao and Najaf Amin and Eric Boerwinkle and C. Bouchard and Abbas Dehghan and Gudny Eir{\'i}ksdott{\'i}r and Roberto Elos{\'u}a and Oscar H. Franco and Christian Gieger and Tamara B. Harris and Serge Hercberg and Albert Hofman and Alan L. James and Andrew D. Johnson and Mika K{\"a}h{\"{o}nen and Kay-Tee Khaw and Zolt{\'a}n Kutalik and Martin G. Larson and Lenore J. Launer and Guo Li and Jianjun Liu and Kiang Liu and Alanna C. Morrison and Gerjan J. Navis and Rick Twee-Hee Ong and George J Papanicolau and Brenda W. J. H. Penninx and Bruce M. Psaty and Leslie J. Raffel and Olli T. Raitakari and Kenneth Rice and Fernando Rivadeneira and Lynda M. Rose and Serena Sanna and Robert A. Scott and David S Siscovick and Ronald P. Stolk and Andr{\'e} G. Uitterlinden and Dhananjay Vaidya and Melanie M. van der Klauw and Ramachandran S. Vasan and Eranga Nishanthie Vithana and Uwe Voelker and Henry V{\"{o}lzke and Hugh C Watkins and Terri L Young and Tin Aung and Murielle Bochud and Martin Farrall and Catharina Annette Hartman and Maris Laan and Edward G. Lakatta and Terho Lehtim{\"a}ki and Ruth Loos and Gavin Lucas and Pierre Meneton and Lyle J. Palmer and Rainer Rettig and Harold Snieder and E. Shyong Tai and Yik-Ying Teo and Pim van der Harst and Nicholas J Wareham and Cisca Wijmenga and Tien Yin Wong and Myriam Fornage and Vilmundur Gudnason and Daniel A. Levy and Walter Palmas and Paul M. Ridker and Jerome I. Rotter and Cornelia Marja van Duijn and Jacqueline C. M. Witteman and Aravinda Chakravarti and Dabeeru C. Rao}, journal={American journal of human genetics}, year={2014}, volume={95 1}, pages={24-38} }