Gene activation by histone and factor acetyltransferases.

  title={Gene activation by histone and factor acetyltransferases.},
  author={Shelley L Berger},
  journal={Current opinion in cell biology},
  volume={11 3},
Persuasive evidence has emerged that acetyltransferases appear to truly function to acetylate both histones and transcription factors in vivo to effect gene activation. In the cell, acetyltransferases have been identified as components of large, multifunctional and evolutionarily conserved macromolecular assemblies, whose components and structures suggest complex functions. In addition, the first atomic resolution structures of HATs have revealed conserved mechanisms of acetyl-CoA interaction… CONTINUE READING

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