Gene activation and protein expression following ischaemic stroke: strategies towards neuroprotection.

  title={Gene activation and protein expression following ischaemic stroke: strategies towards neuroprotection.},
  author={Mark Slevin and Jerzy Krupinski and P. R. Srikanta Kumar and John Gaffney and Shant Kumar},
  journal={Journal of cellular and molecular medicine},
  volume={9 1},
Current understanding of the patho-physiological events that follow acute ischaemic stroke suggests that treatment regimens could be improved by manipulation of gene transcription and protein activation, especially in the penumbra region adjacent to the infarct. An immediate reduction in excitotoxicity in response to hypoxia, as well as the subsequent inflammatory response, and beneficial control of reperfusion via collateral revascularization near the ischaemic border, together with greater… CONTINUE READING


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EGF activates an inducible survival response via the RAS->ERK1/2 pathway to counteract interferon-alphamediated apoptosis in epidermoid cancer

  • M. Caraglia, P. Tagliaferri, +10 authors A. Abbruzzese
  • cells, Cell Death Differ.,
  • 2003
Highly Influential
15 Excerpts

Time-course phosphorylation of the MAP kinase group of signalling proteins and related molecules following middle cerebral artery occlusion in the rat, Neuropath

  • J. Krupinski, M. Slevin, E Marti
  • App. Neurobiol.,
  • 2003
Highly Influential
5 Excerpts

Increased expression of TGF- 1 in brain tissue after ischaemic stoke in humans, Stroke

  • J. Krupinski, P. Kumar, S Kumar
  • 1996
Highly Influential
5 Excerpts

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