Gene Therapy with Lmp1 Causes Upregulation of Bmp-2 , Bmp-7 , and Aggrecan Messenger-rna in Rabbit Intervertebral Discs in Vivo

  • Published 2003
INTRODUCTION: Intervertebral disc degeneration is associated with the loss of disc nucleus proteoglycan content and a reduction in the rate of newly synthesized proteoglycans. (1,2) Aggrecan is a high molecular weight proteoglycan that plays a critical role in disc function by increasing nucleus pulposus hydration. A decrease in aggrecan mRNA level has been… CONTINUE READING