• Corpus ID: 9492600

Gene Therapy for Cancer Treatment

  title={Gene Therapy for Cancer Treatment},
  author={Chetna Thakur},
  journal={Research and reviews: journal of medical and health sciences},
  • Chetna Thakur
  • Published 12 August 2016
  • Medicine
  • Research and reviews: journal of medical and health sciences
ABSTRACT Cancer is an unusual development of cells the proximate reason for which is unevenness in cell expansion and demise getting through the ordinary physiological governing rules framework and a definitive reason for which are one or even more an assortment of quality adjustments. These modifications can be basic, e.g. transformations, insertions, erasures, intensifications, combinations and translocations, or utilitarian (heritable changes without changes in nucleotide succession). No… 
1 Citations

A Systematic Review of Gene Therapy as Treatment of Oral Squamous Cell Carcinoma

Gene therapy has potential as a recent treatment in cases of oral squamous cell carcinoma, and is introducing new genetic material into target cells while causing no damage to surrounding healthy cells and tissue.



Autologous Gene Therapy - A Proactive Approach to Cancer Critique

Gene therapy is quite promising since the body’s immune response is not compromised while targeting the cancerous cell and various characteristic features like less toxicity and ability to induce an immune response make the therapy quite probable for various cancers like pancreatic, ovarian and Glioblastoma.

Suicide Gene Therapy for Cancer - Current Strategies.

Various stages of streamlining of the suicide gene therapy into clinical oncology as applied to different types of cancer are discussed, including cell suicide inducing strategies aimed at preventing stem cell-originated cancerogenesis.

Frontiers in Suicide Gene Therapy of Cancer.

  • M. Małecki
  • Biology, Medicine
    Journal of genetic syndromes & gene therapy
  • 2012
Progress in genomics and proteomics should help us in identifying the cancer specific biomarkers and metabolic pathways for developing new strategies towards clinical trials of targeted and personalized gene therapy of cancer.

Gene therapy: An overview

The objective of gene therapy is to introduce new genetic material into target cells while causing no damage to the surrounding healthy cells and tissues, hence the treatment related morbidity is decreased.

Extending Life: From Stem Cells to Gene Therapy

This report is written for Departmental Heads of the Institute of Public Health (IPH) in Albania, who are in position of developing future healthcare policies, and supporting development programs of “adult stem cells” and “genetic engineering” cures for population at large.

Viral and Non-Viral Gene Therapy for Glioblastoma: New Insights into theTreatment of Malignant Brain Tumors

The principles behind gene therapy and its application to GBM treatment are reviewed, by summarizing recent results obtained both in vitro and pre-clinical studies including the authors’, as well as those reported in patients.

Tumor Compensation Associated With Gene Therapy

Antisense oligonucleotides (oligos) have been employed against in vivo and in vitro cancer models and represent efforts to restore tumor apoptosis by eliminating apoptosis inhibitors bcl-2, or clusterin associated with treatment resistance.

Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas

The results suggested that DPD can be used as a biomarker for selecting glioma patients who may possibly benefit from this therapy, and targeting DNA damage and its repair is a selectable option for gliomas after the standard chemo/radio-therapy.

Potential Hsp90 Inhibitors: A Novel Target for Cancer Therapy

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation, which is why Hsp90 inhibitors are investigated as anti-cancer drugs.

Functional and clinical significance of SALL4 in breast cancer

This review provides an overview concerning the role of SALL4 in BCa development and progression and may identify some drugs/inhibitors for the development of BCa-specific therapies by targeting Sall4.