Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C (*)

@article{Suchnek1995GeneSO,
  title={Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C (*)},
  author={B. Such{\'a}nek and P. H. Seeburg and Rolf Sprengel},
  journal={The Journal of Biological Chemistry},
  year={1995},
  volume={270},
  pages={41 - 44}
}
The murine N-methyl D-aspartate receptor subunit NR2C (-3) is encoded by a unique gene composed of 12 translated and three 5′-untranslated exons that spread over 20 kilobases of genomic sequence. The GC-rich promoter that lacks TATA- and CAAT-positioning elements has two transcriptional start sites separated by 18 base pairs. One of these sites is located in a conserved initiator motif and, together with the first four exons, specifies the 5′-untranslated sequence of 772 nucleotides. In this… 
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The 5′-Untranslated Region of the N-Methyl-D-aspartate Receptor NR2A Subunit Controls Efficiency of Translation (*)
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Comparison of the 5′-deletion constructs in cortical neurons grown for 5, 8, 11, or 14 days in vitro indicate that sequences between −1253 and −1180 bp are necessary for maturational up-regulation of NR2A, suggesting differentcis-acting sequences control the regional and temporal expression of NR1A, implicating distinct regulatory pathways.
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In situ hybridization in human brain revealed the expression of the NR2C mRNA in the pontine reticular formation and lack of expression in substantia nigra pars compacta in contrast to the distribution pattern observed previously in rodent brain.
Characterization of the Rat GRIK5 Kainate Receptor Subunit Gene Promoter and Its Intragenic Regions Involved in Neural Cell Specificity*
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These studies provide evidence for intragenic control of GRIK5promoter activity and suggest that elements contributing to tissue-specific expression are contained within the first exon.
Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase.
TLDR
The complete structure of the murine gene encoding the 67-kD form of glutamic acid decarboxylase (GAD67) is cloned and determined and several putative transcription factor binding sites such as AP2, Hox, E-box, egr-1, and NF-kappaB and putative neuronal-specific regulatory elements are identified, including the neuronal-restrictive silencer element.
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