Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

@inproceedings{Balaskas2012GeneRL,
  title={Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube},
  author={Nikolaos Balaskas and Ana Ribeiro and Jasmina Panovska and Eric Dessaud and Noriaki Sasai and Karen M. Page and James Briscoe and Vanessa Ribes},
  booktitle={Cell},
  year={2012}
}
Secreted signals, known as morphogens, provide the positional information that organizes gene expression and cellular differentiation in many developing tissues. In the vertebrate neural tube, Sonic Hedgehog (Shh) acts as a morphogen to control the pattern of neuronal subtype specification. Using an in vivo reporter of Shh signaling, mouse genetics, and systems modeling, we show that a spatially and temporally changing gradient of Shh signaling is interpreted by the regulatory logic of a… CONTINUE READING

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