Gene Regulation by Thyroid Hormone

@article{Wu2000GeneRB,
  title={Gene Regulation by Thyroid Hormone},
  author={Y. Wu and R. Koenig},
  journal={Trends in Endocrinology & Metabolism},
  year={2000},
  volume={11},
  pages={207-211}
}
  • Y. Wu, R. Koenig
  • Published 2000
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
Regulation of gene expression by thyroid hormones (T3, T4) is mediated via thyroid hormone receptors (TRs). TRs are DNA-binding transcription factors that function as molecular switches in response to ligand. TRs can activate or repress gene transcription depending on the promoter context and ligand-binding status. In most cases, in the absence of ligand, TRs interact with a corepressor complex containing histone deacetylase activity, which actively inhibits transcription. The binding of ligand… Expand
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