Gene Networks Specific for Innate Immunity Define Post-Traumatic Stress Disorder

  title={Gene Networks Specific for Innate Immunity Define Post-Traumatic
Stress Disorder},
  author={Michael S. Breen and Adam X. Maihofer and Stephen J. Glatt and Daniel S. Tylee and Sharon D. Chandler and Ming T. Tsuang and Victoria B Risbrough and Dewleen G. Baker and Daniel T. O’Connor and Caroline M. Nievergelt and Christopher H. Woelk},
  booktitle={Molecular Psychiatry},
The molecular factors involved in the development of Post-Traumatic Stress Disorder (PTSD) remain poorly understood. Previous transcriptomic studies investigating the mechanisms of PTSD apply targeted approaches to identify individual genes under a cross-sectional framework lack a holistic view of the behaviours and properties of these genes at the system-level. Here we sought to apply an unsupervised gene-network based approach to a prospective experimental design using whole-transcriptome RNA… CONTINUE READING
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