Gene Network Analysis of Candidate Loci for Human Anorectal Malformations

  title={Gene Network Analysis of Candidate Loci for Human Anorectal Malformations},
  author={Emily Hoi-Man Wong and Chun-Laam Ng and Vincent Chi-hang Lui and Man-ting So and Stacey Shawn Cherny and Pak C. Sham and Paul Kwong-hang Tam and Maria-Merc{\`e} Garcia-Barcelo},
  booktitle={PloS one},
Anorectal malformations (ARMs) are birth defects that require surgery and carry significant chronic morbidity. Our earlier genome-wide copy number variation (CNV) study had provided a wealth of candidate loci. To find out whether these candidate loci are related to important developmental pathways, we have performed an extensive literature search coupled with the currently available bioinformatics tools. This has allowed us to assign both genic and non-genic CNVs to interrelated pathways known… CONTINUE READING


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