Gene Mutation Patterns in Patients with Minimally Differentiated Acute Myeloid Leukemia☆

  title={Gene Mutation Patterns in Patients with Minimally Differentiated Acute Myeloid Leukemia☆},
  author={Hsiao-Wen Kao and Der-Cherng Liang and Jin-Hou Wu and M C Kuo and P Wang and C P Yang and Yu-Shu Shih and Tung-Huei Lin and Y H Huang and Lee-Yung Shih},
Minimally differentiated acute myeloid leukemia (AML-M0) is a rare subtype of AML with poor prognosis. Although genetic alterations are increasingly reported in AML, the gene mutations have not been comprehensively studied in AML-M0. We aimed to examine a wide spectrum of gene mutations in patients with AML-M0 to determine their clinical relevance. Twenty gene mutations including class I, class II, class III of epigenetic regulators (IDH1, IDH2, TET2, DNMT3A, MLL-PTD, ASXL1, and EZH2), and… CONTINUE READING
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