Gene Mapping in Isolated Populations: New Roles for Old Friends?

@article{Jorde1999GeneMI,
  title={Gene Mapping in Isolated Populations: New Roles for Old Friends?},
  author={L. Jorde and W. Watkins and J. Kere and D. Nyman and A. Eriksson},
  journal={Human Heredity},
  year={1999},
  volume={50},
  pages={57 - 65}
}
Population isolates are increasingly being used in attempts to map genes underlying complex diseases. To further explore the utility of isolates for this purpose, we explore linkage disequilibrium patterns in polymorphisms from two regions (VWF and NF1) in three isolated populations from Finland. At the NF1 locus, the Finnish populations have greater pairwise disequilibrium than populations from Africa, Asia, or northern Europe. However, populations from ‘New Finland’ and ‘Old Finland’ do not… Expand
Linkage disequilibrium patterns vary substantially among populations
Genetics of population isolates
Extensive linkage disequilibrium in small human populations in Eurasia.
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