Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

@inproceedings{Uchida2010GeneKO,
  title={Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis},
  author={Keiko Uchida and Megumi Aramaki and Maki Nakazawa and Chihiro Yamagishi and Shinji Makino and Keiichi Fukuda and Takeshi Nakamura and Takao Takahashi and Katsuhiko Mikoshiba and Hiroyuki Yamagishi},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate various vital processes. Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in embryonic cardiomyocytes, the functions of the IP3Rs in cardiogenesis remain unclear. METHODOLOGY/PRINCIPAL FINDINGS We found that IP3R1(-/-)-IP3R2(-/-) double-mutant mice died in utero with developmental defects of the… CONTINUE READING
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