Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma japonicum

@inproceedings{Cao2013GeneGB,
  title={Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma japonicum},
  author={Yan Cao and Bin Zhao and Yanhui Han and Juan Zhang and Xuezhen Li and Chunhui Qiu and Xiujuan Wu and Yang Hong and Dezhou Ai and Jiaojiao Lin and Zhiqiang Fu},
  booktitle={BioMed research international},
  year={2013}
}
Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to estimate its protection against S. japonicum in BALB/c mice. The DNA vaccine administrated by particle bombardment induced higher protection than by intramuscular injection. All… CONTINUE READING