Gene Expression of Human Lung Cancer Cell Line CL1–5 in Response to a Direct Current Electric Field

  title={Gene Expression of Human Lung Cancer Cell Line CL1–5 in Response to a Direct Current Electric Field},
  author={Chiung-chih Huang and Huai-Yi Chen and Meng-Hua Yen and Jeremy J. W. Chen and T G Young and Ji-Yen Cheng},
  booktitle={PloS one},
BACKGROUND Electrotaxis is the movement of adherent living cells in response to a direct current (dc) electric field (EF) of physiological strength. Highly metastatic human lung cancer cells, CL1-5, exhibit directional migration and orientation under dcEFs. To understand the transcriptional response of CL1-5 cells to a dcEF, microarray analysis was performed in this study. METHODOLOGY/PRINCIPAL FINDINGS A large electric-field chip (LEFC) was designed, fabricated, and used in this study. CL1-5… CONTINUE READING


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