Gene Expression in Aminergic and Peptidergic Cells During Aggression and Defeat: Relevance to Violence, Depression and Drug Abuse

  title={Gene Expression in Aminergic and Peptidergic Cells During Aggression and Defeat: Relevance to Violence, Depression and Drug Abuse},
  author={Klaus A. Miczek and Ella M Nikulina and Aki Takahashi and Herbert E Covington and Jasmine J. Yap and Christopher O. Boyson and Akiko Shimamoto and Rosa M. M. Almeida},
  journal={Behavior Genetics},
In this review, we examine how experiences in social confrontations alter gene expression in mesocorticolimbic cells. The focus is on the target of attack and threat due to the prominent role of social defeat stress in the study of coping mechanisms and victimization. The initial operational definition of the socially defeated mouse by Ginsburg and Allee (1942) enabled the characterization of key endocrine, cardiovascular, and metabolic events during the initial response to an aggressive… 

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