Gene Expression and epigenetic discovery screen reveal methylation of SFRP 2 in prostate cancer

@inproceedings{Perry2014GeneEA,
  title={Gene Expression and epigenetic discovery screen reveal methylation of SFRP 2 in prostate cancer},
  author={Antoinette S. Perry and Gillian O’Hurley and Omer A. Raheem and Kevin Brennan and Simon Wong and Anthony O’Grady and Anne-Marie Kennedy and Laure Marignol and Therese M. Murphy and Linda Sullivan and Ciara Barrett and Barbara M Loftus and J. D. Thornhill and Stephen M. Hewitt and Mark Lawler and Elaine B Kay and Thomas P. Lynch and Donal Hollywood},
  year={2014}
}
Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled-Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives of this study were to (1) profile Wnt signaling related gene expression and (2) investigate methylation of Wnt antagonist genes in prostate cancer. Using TaqMan Low Density Arrays, we identified 15… CONTINUE READING