Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

@article{Chang2004GeneES,
  title={Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds},
  author={Howard Y Chang and Julie B. Sneddon and Ash A. Alizadeh and Ruchira Sood and Robert B. West and Kelli Montgomery and Jen-Tsan Chi and Matt van de Rijn and David Botstein and Patrick O. Brown},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={1657 - 1666}
}
Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in… CONTINUE READING
Highly Influential
This paper has highly influenced 29 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS