Gene Expression Profiling of Depression and Suicide in Human Prefrontal Cortex

  title={Gene Expression Profiling of Depression and Suicide in Human Prefrontal Cortex},
  author={Etienne Sibille and Victoria Arango and Hanga C Galfalvy and Paul Pavlidis and Loubna Erraji-Benchekroun and Steve Ellis and J. John Mann},
Mood disorders are a major cause of disability. Etiology includes genetic and environmental factors, but the responsible genes have yet to be identified. Using DNA microarrays, we have conducted a large-scale gene expression analysis, in two regions of the human prefrontal cortex from post-mortem matched groups of subjects with major depression who had died by suicide, and control subjects who died from other causes and were free from psychiatric disorders. Bioinformatic analysis was used to… CONTINUE READING


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Sex genes as internal controls for genomic analysis: a study in human brain

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Extensive molecular aging in human prefrontal cortex

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