Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus

@inproceedings{Kazezian2015GeneEP,
  title={Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus},
  author={Zepur Kazezian and Rahul Gawri and Lisbet Haglund and Jean Ouellet and Fackson Mwale and Finbarr Tarrant and Peadar O’Gaora and Abhay Pandit and Mauro Alini and Sibylle Grad},
  booktitle={Scientific reports},
  year={2015}
}
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies fail to replace the normal disc in facilitating spinal movements and absorbing load. The focus of regenerative medicine is on identifying biomarkers and signalling pathways to improve our understanding about cascades of disc degeneration and allow for the design of specific therapies. We… CONTINUE READING