Gene Expression Profile of Olfactory Transduction Signaling in an Animal Model of Human Multiple Sclerosis

@inproceedings{Kim2019GeneEP,
  title={Gene Expression Profile of Olfactory Transduction Signaling in an Animal Model of Human Multiple Sclerosis},
  author={Jeongtae Kim and Meejung Ahn and Yuna Choi and Poornima Ekanayake and Chul Min Park and Changjong Moon and Kyungsook Jung and Akane Tanaka and Hiroshi Matsuda and Taekyun Shin},
  booktitle={Experimental neurobiology},
  year={2019}
}
Olfactory dysfunction occurs in multiple sclerosis in humans, as well as in an animal model of experimental autoimmune encephalomyelitis (EAE). The aim of this study was to analyze differentially expressed genes (DEGs) in olfactory bulb of EAE-affected mice by next generation sequencing, with a particular focus on changes in olfaction-related signals. EAE was induced in C57BL/6 mice following immunization with myelin oligodendrocyte glycoprotein and adjuvant. Inflammatory lesions were… CONTINUE READING