Gene Expression Patterns of Dengue Virus-Infected Children from Nicaragua Reveal a Distinct Signature of Increased Metabolism

@inproceedings{Loke2010GeneEP,
  title={Gene Expression Patterns of Dengue Virus-Infected Children from Nicaragua Reveal a Distinct Signature of Increased Metabolism},
  author={P. F. Loke and Samantha Nadia Hammond and Jacqueline M Leung and Charles C. Kim and Sajeev Batra and Crisanta Rocha and {\'A}ngel Balmaseda and Eva Harris},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
BACKGROUND Infection with dengue viruses (DENV) leads to a spectrum of disease outcomes. The pathophysiology of severe versus non-severe manifestations of DENV infection may be driven by host responses, which could be reflected in the transcriptional profiles of peripheral blood immune cells. METHODOLOGY/PRINCIPAL FINDINGS We conducted genome-wide microarray analysis of whole blood RNA from 34 DENV-infected children in Nicaragua collected on days 3-6 of illness, with different disease… CONTINUE READING
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