Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.

@article{Ippolito2016GeneEP,
  title={Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.},
  author={Danielle L. Ippolito and Mohamed Diwan M. AbdulHameed and Gregory J. Tawa and Christine E. Baer and Matthew G Permenter and Bonna C. McDyre and William Erwin Dennis and Molly H. Boyle and Cheryl A. Hobbs and Michael A Streicker and Bobbi S Snowden and John Arban Lewis and Anders Wallqvist and Jonathan D Stallings},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016},
  volume={149 1},
  pages={
          67-88
        }
}
Toxic industrial chemicals induce liver injury, which is difficult to diagnose without invasive procedures. Identifying indicators of end organ injury can complement exposure-based assays and improve predictive power. A multiplexed approach was used to experimentally evaluate a panel of 67 genes predicted to be associated with the fibrosis pathology by computationally mining DrugMatrix, a publicly available repository of gene microarray data. Five-day oral gavage studies in male Sprague Dawley… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 129 REFERENCES

Molecular pathogenesis of liver fibrosis

  • D. A. Brenner
  • Trans. Am. Clin. Climatol. Assoc. 120, 361–368.
  • 2009
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…