Gene Expression Changes in Progression of Cervical Neoplasia Revealed by Microarray Analysis of Cervical Neoplastic Keratinocytes

  title={Gene Expression Changes in Progression of Cervical Neoplasia Revealed by Microarray Analysis of Cervical Neoplastic Keratinocytes},
  author={John Charles Rotondo and Silvia R A Bosi and Cristian Bassi and Manuela Ferracin and Giovanni Lanza and Roberta Gaf{\`a} and Eros Magri and Rita Selvatici and Stefania Torresani and Roberto Marci and Paola Garutti and Massimo Negrini and Mauro Tognon and Fernanda Martini},
  journal={Journal of Cellular Physiology},
To evaluate the gene expression changes involved in neoplastic progression of cervical intraepithelial neoplasia. Using microarray analysis, large‐scale gene expression profile was carried out on HPV16‐CIN2, HPV16‐CIN3, and normal cervical keratinocytes derived from two HPV16‐CIN2, two HPV‐CIN3 lesions, and two corresponding normal cervical tissues, respectively. Differentially expressed genes were analyzed in normal cervical keratinocytes compared with HPV16‐CIN2 keratinocytes and in HPV16… 
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