Gene Expression Analysis of Zebrafish Heart Regeneration

  title={Gene Expression Analysis of Zebrafish Heart Regeneration},
  author={Ching-ling Lien and Michael Schebesta and Shinji Makino and Gerhard J. Weber and Mark T. Keating},
  journal={PLoS Biology},
  pages={1750 - 1757}
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize this process at the molecular level, we generated transcriptional profiles of zebrafish cardiac regeneration by microarray analyses. Distinct gene clusters were identified based on temporal expression patterns. Genes coding for wound response/inflammatory factors, secreted… CONTINUE READING