Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

@article{Liu2015GeneEI,
  title={Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability},
  author={Gaowen Liu and Mei Yun Jacy Yong and Marina Yurieva and Kandhadayar Gopalan Srinivasan and Jaron Liu and John Soon Yew Lim and Michael Poidinger and Graham D Wright and Francesca Zolezzi and Hyungwon Choi and Norman Pavelka and Giulia Rancati},
  journal={Cell},
  year={2015},
  volume={163},
  pages={1388-1399}
}
Gene essentiality is typically determined by assessing the viability of the corresponding mutant cells, but this definition fails to account for the ability of cells to adaptively evolve to genetic perturbations. Here, we performed a stringent screen to assess the degree to which Saccharomyces cerevisiae cells can survive the deletion of ~1,000 individual "essential" genes and found that ~9% of these genetic perturbations could in fact be overcome by adaptive evolution. Our analyses uncovered a… CONTINUE READING
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