Gene Dosage Effects at the Imprinted Gnas Cluster


Genomic imprinting results in parent-of-origin-dependent monoallelic gene expression. Early work showed that distal mouse chromosome 2 is imprinted, as maternal and paternal duplications of the region (with corresponding paternal and maternal deficiencies) give rise to different anomalous phenotypes with early postnatal lethalities. Newborns with maternal… (More)
DOI: 10.1371/journal.pone.0065639


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