Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

@article{Yao1998GeneDE,
  title={Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300},
  author={Tso-pang Yao and Suk Paul Oh and Miriam Fuchs and Nai-Dong Zhou and L E Ch'ng and David Lee Newsome and Roderick Terry Bronson and En Li and David Livingston and Richard Eckner},
  journal={Cell},
  year={1998},
  volume={93},
  pages={361-372}
}
The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene. Animals nullizygous for p300 died between days 9 and 11.5 of gestation, exhibiting defects in neurulation, cell proliferation, and heart development. Cells derived from p300-deficient embryos displayed specific transcriptional defects and proliferated poorly. Surprisingly, p300… CONTINUE READING
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