Gene Conversion (Recombination) Mediates Expansions of CTG·CAG Repeats.*

@inproceedings{Jakupciak2000GeneC,
  title={Gene Conversion (Recombination) Mediates Expansions of CTG·CAG Repeats.*},
  author={John P. Jakupciak and Robert Joseph David Wells},
  year={2000}
}
Abstract Genetic recombination is a robust mechanism for expanding CTG·CAG triplet repeats involved in the etiology of hereditary neurological diseases (Jakupciak, J. P., and Wells, R. D. (1999) J. Biol. Chem. 274, 23468–23479). This two-plasmid recombination system in Escherichia coli with derivatives of pUC19 and pACYC184 was used to investigate the effect of triplet repeat orientation on recombination and extent of expansions; tracts of 36, 50, 80, and 36, 100, and 175 repeats in length… CONTINUE READING

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