Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure

  title={Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure},
  author={Frederick E. Dewey and Marco Valentin Perez and Matthew T. Wheeler and Clifton Watt and Joshua Michael Spin and Peter Langfelder and Steve Horvath and Sridhar Hannenhalli and Thomas P. Cappola and Euan A. Ashley},
  journal={Circulation: Cardiovascular Genetics},
Background—Network analysis techniques allow a more accurate reflection of underlying systems biology to be realized than traditional unidimensional molecular biology approaches. Using gene coexpression network analysis, we define the gene expression network topology of cardiac hypertrophy and failure and the extent of recapitulation of fetal gene expression programs in failing and hypertrophied adult myocardium. Methods and Results—We assembled all myocardial transcript data in the Gene… 

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